Transferrins are iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. Human transferrin is encoded by the TF gene. Transferrin glycoproteins bind iron tightly, but reversibly.
A high TIBC, UIBC, or transferrin usually indicates iron deficiency, but they are also increased in pregnancy and with the use of oral contraceptives. A low TIBC, UIBC, or transferrin may occur if someone has: Hemochromatosis. Certain types of anemia due to accumulated iron. Malnutrition.
Iron in plasma is bound to the transport protein transferrin. Transferrin is responsible for 50% to 70% of the iron-binding capacity of serum. … Transferrin levels rise with iron deficiency and fall in cases of iron overload. An increase in the transferrin is seen in iron deficiency anemia.
The normal range for transferrin is 170 to 370 mg/dl. If you have a higher amount, you may have iron-deficiency anemia. If you have a lower level, you may have another problem, such as liver disease and hemolytic anemia. Transferrin may also be measured using a value called total iron-binding capacity (TIBC).